ECEBM, a GESI member

We are pleased to announce that the Egyptian Center for Evidence Based Medicine (ECEBM), is now a member of the Global Evidence Synthesis Initiative (GESI) Network. Top-tier evidence-synthesis centers from LMIC form the GESI Network. The Network enhances the collaboration between these centers and forms a bridge to share knowledge and experience. The GESI Consortium … Continue reading ECEBM, a GESI member

Multiple treatments comparisons

A special method of meta-analysis known as multiple treatments meta-analysis (MTM) is suited to the practical issues addressed by overviews of reviews. However, MTM (also known as ‘network meta-analysis’, or ‘multiple treatments comparisons’ (‘MTC’) meta-analysis) relies on a strong assumption that studies of different comparisons are similar in all ways other than the interventions being compared.

Key Message: How to reduce the risk of selection bias in RCTs

Probably the simplest and most effective method to prevent selection bias in randomized trials is simple randomization. Simple randomization works by assigning each patient to one of the treatment groups with a 50% probability; this probability is the same for every patient, regardless of previous allocations. For example, consider a trial where 40 of the first … Continue reading Key Message: How to reduce the risk of selection bias in RCTs